Selected Publications:

1: Lu L, Mok BWY, Chen LL, Chan JMC, Tsang OTY, Lam BHS, Chuang VWM, Chu AWH, Chan WM, Ip JD, Chan BPC, Zhang R, Yip CCY, Cheng VCC, Chan KH, Jin DY, Hung IFN, Yuen KY, Chen H, To KKW. Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant by Sera From BNT162b2 or CoronaVac Vaccine Recipients. Clin Infect Dis. 2022 Aug 24;75(1):e822-e826. doi: 10.1093/cid/ciab1041. PMID: 34915551; PMCID: PMC8754807.

2: Yuan S, Ye ZW, Liang R, Tang K, Zhang AJ, Lu G, Ong CP, Man Poon VK, Chan CC, Mok BW, Qin Z, Xie Y, Chu AW, Chan WM, Ip JD, Sun H, Tsang JO, Yuen TT, Chik KK, Chan CC, Cai JP, Luo C, Lu L, Yip CC, Chu H, To KK, Chen H, Jin DY, Yuen KY, Chan JF. Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters. Science. 2022 Jul 22;377(6604):428-433. doi: 10.1126/science.abn8939. Epub 2022 Jun 23. PMID: 35737809.

3: Zhou B, Zhou R, Tang B, Chan JF, Luo M, Peng Q, Yuan S, Liu H, Mok BW, Chen B, Wang P, Poon VK, Chu H, Chan CC, Tsang JO, Chan CC, Au KK, Man HO, Lu L, To KK, Chen H, Yuen KY, Dang S, Chen Z. A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge. Nat Commun. 2022 Jun 23;13(1):3589. doi: 10.1038/s41467-022-31259-7. PMID: 35739114; PMCID: PMC9223271.

4: Zhou R, Wang P, Wong YC, Xu H, Lau SY, Liu L, Mok BW, Peng Q, Liu N, Woo KF, Deng S, Tam RC, Huang H, Zhang AJ, Zhou D, Zhou B, Chan CY, Du Z, Yang D, Au KK, Yuen KY, Chen H, Chen Z. Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination in mouse models. EBioMedicine. 2022 Jan;75:103762. doi: 10.1016/j.ebiom.2021.103762. Epub 2021 Dec 21. PMID: 34942445; PMCID: PMC8687884.

5: Mok BW, Liu H, Deng S, Liu J, Zhang AJ, Lau SY, Liu S, Tam RC, Cremin CJ, Ng TT, Leung JS, Lee LK, Wang P, To KK, Chan JF, Chan KH, Yuen KY, Siu GK, Chen H. Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters. Commun Biol. 2021 Sep 20;4(1):1102. doi: 10.1038/s42003-021-02640-x. PMID: 34545191; PMCID: PMC8452646.

6: Wong YC, Lau SY, Wang To KK, Mok BWY, Li X, Wang P, Deng S, Woo KF, Du Z, Li C, Zhou J, Chan JFW, Yuen KY, Chen H, Chen Z. Natural Transmission of Bat-like Severe Acute Respiratory Syndrome Coronavirus 2 Without Proline-Arginine-Arginine-Alanine Variants in Coronavirus Disease 2019 Patients. Clin Infect Dis. 2021 Jul 15;73(2):e437-e444. doi: 10.1093/cid/ciaa953. PMID: 32649739; PMCID: PMC7454488.

7: Liu S, Mok BW, Deng S, Liu H, Wang P, Song W, Chen P, Huang X, Zheng M, Lau SY, Cremin CJ, Tam CY, Li B, Jiang L, Chen Y, Yuen KY, Chen H. Mammalian cells use the autophagy process to restrict avian influenza virus replication. Cell Rep. 2021 Jun 8;35(10):109213. doi: 10.1016/j.celrep.2021.109213. PMID: 34107256.

8: Wang P, Lau SY, Deng S, Chen P, Mok BW, Zhang AJ, Lee AC, Chan KH, Tam RC, Xu H, Zhou R, Song W, Liu L, To KK, Chan JF, Chen Z, Yuen KY, Chen H. Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein. Nat Commun. 2021 May 13;12(1):2790. doi: 10.1038/s41467-021-23166-0. PMID: 33986286; PMCID: PMC8119425.

9: Lau SY, Wang P, Mok BW, Zhang AJ, Chu H, Lee AC, Deng S, Chen P, Chan KH, Song W, Chen Z, To KK, Chan JF, Yuen KY, Chen H. Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction. Emerg Microbes Infect. 2020 Dec;9(1):837-842. doi: 10.1080/22221751.2020.1756700. PMID: 32301390; PMCID: PMC7241555.

10: Wang P, Zheng M, Lau SY, Chen P, Mok BW, Liu S, Liu H, Huang X, Cremin CJ, Song W, Chen Y, Wong YC, Huang H, To KK, Chen Z, Xia N, Yuen KY, Chen H. Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines. mBio. 2019 Sep 17;10(5):e02180-19. doi: 10.1128/mBio.02180-19. PMID: 31530680; PMCID: PMC6751066.

11: Mok BW, Liu H, Chen P, Liu S, Lau SY, Huang X, Liu YC, Wang P, Yuen KY, Chen H. The role of nuclear NS1 protein in highly pathogenic H5N1 influenza viruses. Microbes Infect. 2017 Dec;19(12):587-596. doi: 10.1016/j.micinf.2017.08.011. Epub 2017 Sep 10. PMID: 28903072.

12: Huang X, Zheng M, Wang P, Mok BW, Liu S, Lau SY, Chen P, Liu YC, Liu H, Chen Y, Song W, Yuen KY, Chen H. An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells. Nat Commun. 2017 Mar 21;8:14751. doi: 10.1038/ncomms14751. PMID: 28323816; PMCID: PMC5364394.

13: Zheng M, Wang P, Song W, Lau SY, Liu S, Huang X, Mok BW, Liu YC, Chen Y, Yuen KY, Chen H. An A14U Substitution in the 3' Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs. J Virol. 2015 Oct;89(20):10273-85. doi: 10.1128/JVI.00919-15. Epub 2015 Jul 29. PMID: 26223635; PMCID: PMC4580205.

14: Song W, Wang P, Mok BW, Lau SY, Huang X, Wu WL, Zheng M, Wen X, Yang S, Chen Y, Li L, Yuen KY, Chen H. The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication. Nat Commun. 2014 Nov 20;5:5509. doi: 10.1038/ncomms6509. PMID: 25409547; PMCID: PMC4263149.

15: Wen X, Huang X, Mok BW, Chen Y, Zheng M, Lau SY, Wang P, Song W, Jin DY, Yuen KY, Chen H. NF90 exerts antiviral activity through regulation of PKR phosphorylation and stress granules in infected cells. J Immunol. 2014 Apr 15;192(8):3753-64. doi: 10.4049/jimmunol.1302813. Epub 2014 Mar 12. PMID: 24623135.

16: Mok BW, Song W, Wang P, Tai H, Chen Y, Zheng M, Wen X, Lau SY, Wu WL, Matsumoto K, Yuen KY, Chen H. The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection. J Virol. 2012 Dec;86(23):12695-707. doi: 10.1128/JVI.00647-12. Epub 2012 Sep 12. PMID: 22973032; PMCID: PMC3497642.

17: Wu WL, Lau SY, Chen Y, Wang G, Mok BW, Wen X, Wang P, Song W, Lin T, Chan KH, Yuen KY, Chen H. The 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: Implications for the prevalence of oseltamivir resistant variant viruses. Antiviral Res. 2012 Jan;93(1):144-53. doi: 10.1016/j.antiviral.2011.11.006. Epub 2011 Nov 25. PMID: 22138712; PMCID:

PMC3243069.